Windows only: Until Google graces us with a real extension manager, an enterprising user put together an impressive batch file that can handle enabling, disabling, or even uninstalling Google Chrome extensions.
Once you've downloaded the batch file, you can simply double-click to open it up in a command prompt window, where you'll be presented with a menu that allows you to enable, disable, or uninstall extensions, or even run Chrome with extensions enabled. It's definitely not the ideal way to deal with add-ons, but it's a great, workable solution until Google puts a real extension manager together—and you have to admire those kind of batch scripting skills.
Hit the link for the download, and remember to right-click the batch file download link and Save As, giving the file a *.bat extension.
Windows: There are a lot of great add-ons for Microsoft’s premier productivity product, but there’s no central spot to turn them on or off. TopAlt EnableDisable controls