Windows only: Backup Maker offers extremely simple wizard-driven backup to a variety of local media and remote hosts.
Whether you’d like to backup to another disk, burn the files to a CD, or transfer them to a remote FTP site, Backup Maker has a variety of solutions to backup your data. It handles both the backup and the restoration of files and has an easy to use wizard for creation of scheduled backup routines. You can specify whether files are to be completely overwritten each time or only incrementally with files being replaced and added as they are altered. Restoration is just as simple with point and click dumping of your data from the backup to the previous location. The software is free, although after batch backups a nag screen does pop up suggesting potential upgrades to other software offered by the company. For other backup solutions, minus the pop up screen, make sure to check out the Hive Five for backup tools. Backup Maker is freeware, Windows only.
Windows/Mac/Linux: Java-based DirSync Pro provides cross-platform file synchronization with an easy to use interface, incremental backup, and a profile system.